Chicago Mercantile Exchange (NASDAQ: CME) is now in the second spot right behind Binance for the largest Bitcoin (CRYPTO: BTC) futures exchange driven by an institutional-led rally amid the spot ETF optimism. The regulated exchange jumped from the fourth position which was seen a few weeks ago. Reporting a notional open interest of $3.54 billion, CME stands behind Binance which reports $3.83 billion in open interest, according to CoinDesk based on CoinGlass data. Industry titans BlackRock, DTCC, OCC, State Street, Société Générale, Hedera, Citi, BMO, Northern Trust, Citibank, Amazon, S&P Globa…